CEBPA and acute myeloid leukemia: Most patients have more than one mutation in CEBPα; the most common scenario is the combination of two mutations in different alleles, a mutation that blocks transcription of p42 and one in the bZIP, which are associated with favorable prognosis, as well as AML without maturation (FAB subtype M0) and AML with maturation (FAB subtype M2).44,46,47