(2) A postnatal high-fat diet results in increased blood pressure, increased central and peripheral insulin resistance, decreased expression levels of SIRT1, adiponectin, and BDNF, as well as increased expression levels of phospho-PPARγ, phospho-IRS1, TNF-α, and p66Shc in the dorsal hippocampus. The gene discussed is SIRT1; the disease is Insulin resistance.