CAV1 and cancer: In order to study the signaling pathways involved in CAV1 up-regulation, induced by anti-neoplastic drugs, cancer cells were treated with either the PI3K inhibitor LY294002 (10 μM), the MEK inhibitor PD98059 (50 μM) or with the antioxidant Trolox (2 mM), prior to addition of Methotrexate or Etoposide.