Importantly, in both HT29(US) and DLD-1 cells, activation of MMP9 and MMP2 was reduced in cells where CAV1 expression had been silenced, in agreement with data reported in the literature linking CAV1 expression to the transcriptional upregulation of metalloproteinases in vascular smooth muscle cells [40] and cancer cells [41]. Here, MMP9 is linked to cancer.