In this study, our study aims to find the relationship between IGF-1R and EMT biomarkers (E-cadherin, N-cadherin, Vimentin, Snail1, Snail2, Twist1) in HCC samples, and then we determined the impact of IGF-1 on cell proliferation, migration and invasion of HCC cells using in vitro assay. Here, SNAI2 is linked to hepatocellular carcinoma.