IGF1 and Familial prostate cancer: Compared with other previous studies [20], Graham TR et al reported that IGF-I up-regulates the expression of ZEB1 in prostate cancer cells that exhibits a mesenchymal phenotype, however, ZEB1 inhibition abrogated the inhibition of E-cadherin protein, and further down-regulates the expression of N-cadherin and fibronectin proteins.