The rate of tumor formation in the peritoneal organs was increased in the PrSC group compared with the Ctrl group and in the HFD group compared with the HFD+BMS group, and the total metastasis rates were calculated (P=0.003 in the PrSC group compared with the Ctrl group, and P=0.028 and P=0.034 in the HFD group compared with the Ctrl and HFD+BMS groups, respectively Figure 4C). This evidence concerns the gene CORIN and neoplasm.