To investigate the direct role of FABP4 in PCa cell proliferation and invasion, we compared the proliferation rate and invasive capacity of PC-3 cells treated with FABP4 siRNAs (50 nM) or rFABP4 (30 and 100 ng ml-1) with that of untreated PC-3 cells. The gene discussed is FABP4; the disease is posterior cortical atrophy.