Inhibition of SNHG1 dramatically restrained the growth of colorectal cancer cells by MTS assay and colony formation, arrested cell cycle and induced the cell apoptosis by flow cytometry, as well as attenuated migration and invasion of CRC cells by transwell assay in vitro, indicating that SNHG1 may serve as an oncogene that promotes CRC malignant progression. The gene discussed is SNHG1; the disease is colorectal carcinoma.