SNHG1 and Familial prostate cancer: SNHG1 has been shown to be strikingly increased in several cancer and up-regulation of SNHG1 indicated the poor prognosis of tumor patients, and silencing of SNHG1 expression contributed to suppression of cancer cell proliferation or growth, diminishment of migration and invasion, inducement of apoptosis in non-small cell lung cancer, prostate cancer, glioma, primary esophageal cancer cells and hepatocellular carcinoma [13, 14, 16, 17, 30].