AGGF1 and cirrhosis of liver: In the next step, AGGF1, VEGF and MVD, together with liver cirrhosis and BCLC staging were included in a multivariate Cox proportional hazards analysis and AGGF1 (HR = 2.164; 95% CI: 1.09-4.30; P= 0.028, Table 3), liver cirrhosis and BCLC staging turn out to be independent prognostic factors for DFS.