Nuclear translocation of p50 and p65 were observed in the brain areas surrounding the necrotic infarct core of patients who suffered a stroke or rats subjected to middle cerebral artery occlusion (MCAO) [31, 33], while the inhibition of NF-κB in neurons resulted in a significant and comparable reduction in infarct size in both transient and permanent stroke models [34, 35], suggesting that NF-κB plays a detrimental role in cerebral ischemia. This evidence concerns the gene RELA and brain ischemia.