AKT1 and cancer: Many of these pathways were linked to cancer, such as “pathways in cancer” (P = 0.028), “cytokine-cytokine receptor interaction” (P = 8.54E-6), which was in accordance with an early research [2], “PPAR signaling pathway” (P = 0.022), which was particularly associated with THCA [26, 27], and “PI3K-Akt signaling pathway” (P = 1.63E-4), which was one of the most important molecular mechanisms identified in the carcinogenesis of THCA [28].