TP53 and cancer: Except for those GO functional terms that seemed conflicting in function, some important KEGG pathways that are involved in cancers were also enriched, such as “TNF signaling pathway” (P = 0.003), “p53 signaling pathway” (P = 0.003), “MAPK signaling pathway” (P = 0.028) which was reported by different studies on THCA [2, 4, 17, 28], and “PI3K-Akt signaling pathway” (P = 0.04), showing that the lncRNA LA16c-380H5.2 may promote normal growth and development of thyroid cells.