A uniquely enriched pathway of all five PCGs (FSTL3, KLF6, MLF1, NR4A3, and SDC4) was “Transcriptional misregulation in cancer” (P = 0.048), suggesting that those five PCGs and their regulating lncRNAs may play roles in transcriptional regulation levels in THCA. This evidence concerns the gene KLF6 and cancer.