A decrease of E-cadherin expression is closely related to tumor development, invasion and metastasis [41], and studies have shown that E-cadherin inhibits the Wnt/β-catenin pathway through its binding at the C-terminal domain of β-catenin at the plasma membrane, thereby sequestering β-catenin from the cytoplasmic pool [42]. Here, CDH1 is linked to neoplasm.