AIF1 and Miyoshi myopathy: Because the OXPHOS pathway is significantly activated in both bortezomib-resistant and relapsed MM cells, and PAA, in the presence of iron, leads to the formation of ROS resulting in AIF1 cleavage and translocation from the mitochondria to the nucleus with consequent cell death, we hypothesized that the signaling pathway of MitoBio might be involved in PAA-induced MM death.