EGFL6 is expressed primarily in the vasculature and is not expressed by SKOV3 cells, so to assess the effect of EGFL6 in-vivo, we initiated tumors using SKOV3 cells co-injected with control hemangioma stem cell (HemSC) derived endothelial cells or HemSC derived endothelial cells expressing EGFL6. The gene discussed is EGFL6; the disease is hemangioma.