SH2B3 and rheumatoid arthritis: However, after reviewing the location of the reported RA-associated variants, we found that only 9 of over 200 variants are located in the exome area, including CTLA4 (rs231775), FCGR2A (rs1801274), IL6R (rs2228145), OLIG3 (rs2230926), PTPN22 (rs2476601), RTKN2 (rs3125734), SH2B3 (rs3184504), TNFAIP3 (rs223092) and TYK2 (rs34536443).