Additional pathogenic variant of OXCT1 (3-Oxoacid CoA-Transferase 1) was predicted to be damaging (disease-related, D) in our RA patients, encoding Succinyl-CoA:3-ketoacid coenzyme A transferase 1 (SCOT1), which is a key enzyme for synthesis and degradation of ketone bodies involved in cardiovascular disease [18, 19]. This evidence concerns the gene OXCT1 and rheumatoid arthritis.