However, after reviewing the location of the reported RA-associated variants, we found that very few variants are located in the exome area, including CTLA4 (rs231775), FCGR2A (rs1801274), IL6R (rs2228145), OLIG3 (rs2230926), PTPN22 (rs2476601), RTKN2 (rs3125734), SH2B3 (rs3184504), TNFAIP3 (rs223092) and TYK2 (rs34536443). Here, TYK2 is linked to rheumatoid arthritis.