TP53 and neoplasm: In contrast, SIRT1 may play a tumor-suppressor role in the TNBC subtype, in line with Yi et al. [34] who reported that the activation of SIRT1 by a SIRT1-specific activator YK-3-237 induced deacetylation of the mutant form of p53 (mtp53), suppressing the proliferation and arresting the cell growth of triple-negative breast cancer cell lines.