SIRT1 and cancer: Studies using this approach report that SIRT1 is upregulated in a spectrum of cancers including, but not limited to, liver cancer [14], acute myeloid leukemia [15], bone cancer [16], thyroid cancer [17] and skin cancer [18], but downregulated in other cancers including colon cancer [12], oral squamous cell carcinoma [19], glioblastoma and ovarian cancer [20].