A significant decrease in the cell viability was observed over time in glioma cells with low miR-19a/b expression compared with the cells that had no transfection of AS-miR-19 as observed with the MTT assay, moreover, knockdown of RUNX3 in cells transfected with AS-miR-19a/b partly abolished the effect on the cell prolification of AS-miR-19a/b (Figure 3A). The gene discussed is RUNX3; the disease is central nervous system cancer.