On the other hand, even if there is a great probability that several SNPs are involved in the observed final physiological response in subjects under a dietary intervention, the SNPs − 21A>T CAT (rs7943316) and 47C>T SOD2 (rs4880) reported in the present work could be used in future studies as a genetic tool to improve the treatment of overweight and obesity as well as to identify, trace, and evaluate the risk to develop several comorbidities of obesity. This evidence concerns the gene SOD2 and obesity due to melanocortin 4 receptor deficiency.