In the multivariate logistic regression analysis entering age, sex, smoking pack-year, beta blocker use, diabetes, causes of CKD, heart rate, pulse pressure, serum levels of calcium and phosphorus, eGFR, logarithm of UPCR, bilirubin, albumin, cholesterol, and hemoglobin as covariates, the odds for a rapid decline in the eGFR were 1.9 times higher in the 5Q of the baPWV than in the 1Q of the baPWV (95% CI = 1.141–3.129; P = 0.013), suggesting that there was a non-linear association between the baPWV and a rapid decline in the eGFR. This evidence concerns the gene ALB and diabetes mellitus.