As shown in Fig. 4b, tissue samples that had higher expression of FUT8, except Lane 8, had a significantly lower PSA production and vice versa, which was in accordance with our in vitro western blot analysis (Fig. 4a) suggesting the inhibitory role of FUT8 on the PSA expression in metastatic prostate cancer tissues. The gene discussed is KLK3; the disease is metastatic prostate carcinoma.