RNF43 and malignant colon neoplasm: In this respect, colon cancer-related genes as well as Wnt target genes (Jun, Axin2, Pvrl4, Rnf43, Tnfrsf11b, Ephb3) were among the top up-regulated DEGs in susceptible mice following infection while genes highly expressed in differentiated cells and genes negatively correlated with CRC or IBD (Slc26a3, Car4, Tmigd1, Mep1b, Clca6, Agr2, Zg16) were found to be among the top down-regulated DEGs (Table 2).