Taken together, our data demonstrate that C. rodentium infection of susceptible inbred mice may mimic CRC pathogenesis through Rspo2-mediated signaling: induction of Rspo2 expression activates β-catenin and induces excessive epithelial proliferation accompanied by a loss of functional cell types including mucin-secreting goblet cells. The gene discussed is MUC5AC; the disease is colorectal carcinoma.