HIF1A and lung cancer: Moreover, a recent review conducted by Gladek et al. [16] showed that HIF1A gene rs10873142 polymorphism is associated with the risk of coronary artery disease with stable exertional angina [22] and idiopathic osteonecrosis of the femoral head in men [23], while not associated with acute myocardial infarction and frequent intradialytic hypotension [17], early-onset pre-eclampsia [17], lung cancer [18], and COPD [14].