For instance, SF3B1, which encodes an RNA-splicing factor and is orthologous to let-763/sftb-1, has mutations related to myeloid cancers and refractory anemias (Papaemmanuil et al. 2011; Broseus et al. 2013). This evidence concerns the gene SF3B1 and myelodysplastic syndrome with single lineage dysplasia.