CDC7 overexpression was also correlated with P53 inactivation5 and has been found in many human tumor cell lines and tissues, including breast, colon and lung cancers, melanoma and oral squamous cell carcinoma (OSCC), but this protein has very low or undetectable expression in normal tissues.2, 5, 6, 7, 8, 9, 10. The gene discussed is CDC7; the disease is lung cancer.