Various adhesion-related molecules (Icam-1, Vcam-1, Itgb-1/2, and Cd44) were up-regulated in the hippocampus of ADLPAPT mice (Fig. 6a and b), indicating that AD pathologies can modulate endothelial cells in the brain parenchyma and recruit peripheral immune [59]. The gene discussed is ICAM1; the disease is Alzheimer disease.