Interestingly, studies performed in mouse models of viral infection in the CNS have shown that CCL19 and CCL21 produced in the meninges are crucial to support recruitment and local reactivation of antiviral CD8+ T cells [65] and that the meninges are a preferential site of accumulation and activity of virus-specific tissue-resident CD8+ memory T cells [66]. Here, CD8A is linked to viral infectious disease.