After adjusting for age, sex, BMI, blood pressure, duration of diabetes, HbA1c, LDL-C and TC, common variants of the Hp gene exhibited a significant association with macroangiopathies (OR = 1.140 [95% CI 1.005–1.293], P = 0.0410 for the Hp 1 allele). The gene discussed is HP; the disease is diabetes mellitus.