There was no significant difference between the groups regarding age, sex, duration of diabetes, BMI, body weight, insulin dose requirement, waist circumference, systolic and diastolic blood pressure, lipids, hypertension, dyslipidemia, overweight/obesity and prevalence, and risk factors of metabolic syndrome before treatment (p > 0.05) (Table 1). The gene discussed is INS; the disease is Hypertension.