There was no significant difference between the groups regarding age, sex, duration of diabetes, BMI, body weight, insulin dose requirement, waist circumference, systolic and diastolic blood pressure, lipids, hypertension, dyslipidemia, overweight/obesity and prevalence, and risk factors of metabolic syndrome before treatment (p > 0.05) (Table 1). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.