ESR1 and Hyperbilirubinemia: After a period of time, hepatocyte repopulation succeeds with the maturation of hepatocyte progenitors, recovery from hyperbilirubinemia, gradual return of liver function test values to normal within postoperative 30 d, and favorable survival rate.38,39 Thus, the E2/ERα-CYP2A6 axis discovered in this report plays a role in functional recovery after hepatocyte repopulation.