Lastly, Se deficiency in WSB mice, a model resistant to diet-induced obesity with low fasting insulin, consistently caused greater decreases in expression of Txnrd3 Gpx4, Selenof, Gpx3, Msrb1, and Selenoo transcripts than in B6 mice, even though they were 2 wk older at the start of feeding the Se deficient diet, and growing twice as slowly as B6 mice. The gene discussed is SELENOO; the disease is obesity due to melanocortin 4 receptor deficiency.