In A431 epidermoid carcinoma cells exposed to lysophosphatidic acid that forces rapid dissociation of adherens junctions, cadherin-bound β-catenin was internalized together with E-cadherin, accumulated at the perinuclear endocytic recycling compartment, and translocated into the nucleus, suggesting that dissociation of adherens junctions can affect β-catenin levels available for the Wnt/β-catenin pathway [67]. This evidence concerns the gene CDH1 and squamous cell carcinoma.