Importantly, mutations of human CDH3 (the gene encoding P-cadherin) cause two rare autosomal recessive disorders: Hypotrichosis with Juvenile Macular Dystrophy (HJMD) [29–32] and Ectodermal Dysplasia, Ectrodactyly, and Macular Dystrophy (EEM syndrome) [33]. Here, CDH3 is linked to EEM syndrome.