In order to realize whether TRPV1 is involved in the synergistic anti-cancer effect, the selective TRPV1 antagonist SB-705498 ((N-(2-bromophenyl)-N’-[((R)-1-(5-tri-fluromethyl-2-pyridyl)pyrrolidin-3-yl)]urea) was incubated with the cells 30 min before SMF and capsaicin treatments [28]. This evidence concerns the gene TRPV1 and cancer.