SW480 is a human colon cancer cell line with APC C-terminal truncation at 1338, but the β-catenin binding region is retained; HCT116 is a highly metastatic cell line with WT APC and both an S45 mutation and the WT allele for β-catenin, but most of the β-catenin protein comes from the mutant allele. This evidence concerns the gene APC and colonic neoplasm.