An interesting application is the use of Nps in combination with siRNAs; it is known that stimulation of the thyrosin kinase receptor c-Met induces proliferation of glioma cells and resistance to chemotherapy; intravenous administration of polyethylene glicol (PEG) Nps loaded with c-Met siRNA reduced c-Met expression and powerfully inhibited cell proliferation and resistance to chemotherapeutic agents in GBM cells [34]. The gene discussed is MET; the disease is central nervous system cancer.