Heaton et al. utilized CRISPRa system to identify Influenza virus restriction factors on a genomic scale level and found Beta-1,4-N-Acetyl-Galactosaminyltransferase 2 (B4GALNT2) can inhibit several Influenza virus strains binding to α 2,3 linked sialic acid receptor to abolish infection [199]. The gene discussed is B4GALNT2; the disease is infection.