MYD88 and hepatocellular carcinoma: A study found that when HBV-replicating plasmids co-transfected with the TLR adaptors MyD88 and TRIF, or RLR adaptor IPS expression plasmids into hepatoma cells, the replication and antigen expression of HBV were suppressed [19], which was independent of the cytokines released from transfected hepatoma cells.