Consequently, the 2011 study of Kodaglou et al. pointed out that inflammatory pathways are the link between obesity and coronary heart diseases, vaspin serum levels showed an inverse association with acute cardiac ischemic events, so low vaspin concentrations were correlated with ACS severity, which is suggestive of the cardio-protective effects of vaspin [31]. Here, SERPINA12 is linked to obesity due to melanocortin 4 receptor deficiency.