Although some research has shown that c‐myc works together with AP4 to regulate tumour pathogenesis (Xue et al., 2016) or that AP4 regulates the Wnt signalling pathway (Lebensohn et al., 2016), which also involves c‐myc, our report is the first to show that AP4 also regulates c‐myc by affecting LAPTM4B expression. This evidence concerns the gene TFAP4 and neoplasm.