As mutations in human PINK1 (PARK6) and Parkin (PARK2) are causative for early-onset Parkinson's disease (PD), aberrant mitophagy has emerged as an attractive hypothesis to explain the pathophysiology of this neurodegenerative movement disorder (McWilliams and Muqit, 2017, Whitworth and Pallanck, 2017). Here, PRKN is linked to Parkinson disease.