BRCA1 and cancer: Deaths due to non-breast malignancies included six (3%) of 201 new primary cancers in BRCA1 mutation carriers (three ovarian, one primary peritoneal, one oesophageal, and one pancreatic) and 12 (<1%) of 2395 malignancies in BRCA-negative patients (four haematological, three lung, and one each of brain, colorectal, gastric, pancreatic, and sarcoma; appendix p 8).