Furthermore, amphiphilic α-CD derivatives could be functionalised on the secondary hydroxyl groups by targeting moieties such as folate38 or by incorporating the fragment antigen-binding (Fab) of a monoclonal antibody onto CDs to target IL-3 receptor α-chain (IL-3Rα, highly expressed on AML LSCs).24 Here, IL3RA is linked to acute myeloid leukemia.