MTHFD2 and lung adenocarcinoma: One of the miRNA/mRNA pairs we identified as relevant following treatment with pemetrexed was hsa-miR-202 and one of its predicted targets MTHFD2. Our in vitro findings support a role for MTHFD2 in determining the cellular response of LCLs and A549 cells to pemetrexed, while molecular profiling analysis of 230 lung adenocarcinoma patients from TCGA indicates that amplification or upregulation of MTHFD2 is associated with shorter survival.