Molecular profiling analysis of lung adenocarcinoma samples (N = 230 patients) from TCGA indicates that alterations in MTHFD2 and in two thiol proteases, UCHL1 and UCHL3, in the form of amplification or mRNA upregulation, are associated with shorter median survival (although drug regimen is not reported in this dataset). This evidence concerns the gene MTHFD2 and lung adenocarcinoma.