Volkers et al. compared temperature effects on NaV1.1 wild-type, R859H, and R865G and showed LoF gating defects in both mutants at FT38; Peters et al. showed that the Dravet syndrome associated NaV1.1 mutant (p.A1273V) undergoes depolarization shifts in both steady state activation(LoF) and inactivation(GoF) at FT39. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.