More importantly, fibroblasts educated by exosomes from high-metastatic cancer cells expressed higher level of pro-inflammatory genes, such as IL-1β, IL-6, IL-8, TGF-β, CXCL12, Collagen type I (COL1A1), Collagen type III (COL3A1), and Collagen type IV (COL4A1), which have important roles in modulating the inflammation microenvironment and promoting carcinoma development (Fig. 1f). This evidence concerns the gene IL1B and carcinoma.