In the invasion assay on PC3 that is ALCAMHigh and EphA2High, both the ALCAM-guided H3/E34N19 and the EphA2-guided RYR/E34N19, but not the control bispecific C10/E34N19, effectively inhibited PC3 invasion (Fig. 5d); (4) effects on Wnt3a-dependent tumor cell (A549 and HCT116) proliferation. The gene discussed is EPHA2; the disease is neoplasm.