CD19 and systemic lupus erythematosus: Bosma A et al. reported that normalization of CD1d expression on newly repopulated CD19+CD24hiCD38hi B cells corresponded to normalization of the invariant natural killer T (iNKT) cell number and function in SLE patients treated with rituximab, suggesting that Breg cells are critical in maintaining invariant natural killer (iNKT) cell homeostasis in humans27,28.