In addition, IL-10 is an important anti-inflammatory cytokine and several studies showed that the level of IL-10 was decreased in T cell mediated autoimmune diseases, such as diabetes, psoriasis and rheumatoid arthritis, which indicates that decreased levels of IL-10 may cause activation of T cells, further leading to autoimmune diseases36,37. The gene discussed is IL10; the disease is rheumatoid arthritis.