Curiously, in addition to genes related to monocytes and inflammation, the Yellow gene cluster includes multiple toll-like receptors (TLRs) known to be involved in innate responses (TLR1, 4, 5, 6, 7, and 8) that have been previously identified as part of early (Day 3) gene signatures positively predicting antibody responses to seasonal influenza vaccine25,51. The gene discussed is TLR1; the disease is influenza.