BCL2 and lymphoma: To interrogate whether VavP-Bcl2+Aicda tumors also exhibited more diverse cytosine methylation patterning, we examined pairwise methylation distance between cytosine methylation profiles and found that VavP-Bcl2+Aicda lymphomas indeed manifested greater global inter-tumor heterogeneity than their VavP-Bcl2 counterparts (Fig. 2a; Wilcoxon's P = 0.00112).