To explore whether Aicda-overexpressing lymphomas manifested differences in cytosine methylation distribution, we performed enhanced reduced representation bisulfite sequencing (ERRBS), a quantitative single-nucleotide resolution methylome sequencing technique15, on VavP-Bcl2+Aicda (n = 7) and VavP-Bcl2 (n = 6) lymphoma B-cell populations. Here, BCL2 is linked to lymphoma.