MYC and diffuse large B-cell lymphoma: Pathway analysis of the leading edges from murine and human lymphoma GSEAs (i.e., that exhibit decreased gene expression in AICDA-high tumors) showed enrichment for gene signatures associated with DLBCL, including p53 target genes, MYC repressed genes, and BCL6 target genes, as well as genes involved in GC exit, B-cell receptor signaling, and apoptosis (Supplementary Fig. 8e and Supplementary Data 2).