In childhood acute lymphoblastic leukemia (ALL), six regions that have replicated in several populations are now considered known susceptibility loci (likely representing associations with ARID5B, IKZF1, CEBPE, CDKN2A, PIP4K2A, and GATA3), with the majority of the evidence supported through studies conducted in populations of European and Hispanic descent1,2. Here, CEBPE is linked to acute lymphoblastic leukemia.