Gains in statistical power achieved by recent meta-analyses of childhood ALL genome-wide association studies (GWAS) have resulted in the identification of risk-associated single nucleotide polymorphisms (SNPs) of comparatively lower allele frequencies and estimated magnitude of effects including those tagging the CDKN2B, LHPP, and ELK3 genes3,4. This evidence concerns the gene CDKN2B and acute lymphoblastic leukemia.