To confirm whether USP13 dictated the stability of MCL1 protein in tumor cells, we introduced two independent siRNAs against USP13 into several lung cancer (SW-1573, NCI-H441 and A549) and ovarian cancer (TOV-21G, HEY and OVCA433) cell lines (Fig. 3a). The gene discussed is MCL1; the disease is ovarian carcinoma.