Among the 20 candidate MCL1-regulating DUBs, USP13 drew our attention because it was amplified in several types of human cancer (Fig. 1c), particularly in 45.9% of lung squamous cell carcinoma (504 samples) and 28% of ovarian serous adenocarcinoma (603 samples). The gene discussed is MCL1; the disease is ovarian serous adenocarcinoma.