We focused on PP2A and PP1, two major eukaryotic protein phosphatases that are reported to contribute to >90% of serine/threonine dephosphorylation and regulate a variety of cellular processes through the dephosphorylation of distinct substrates28, and we initially sought to determine if genetic alterations to either of these protein phosphatases could help establish a role in the context of metastatic cancer. The gene discussed is PTPA; the disease is metastatic malignant neoplasm.