Thus, the aim of our study was to assess the expression of membrane fatty acid handling proteins (FAT/CD36, FABPpm, FATP-4) at the mRNA and protein level in the SAT and VAT of patients with obesity, as well as the expression of lipoprotein lipase (LPL), peroxisome proliferator-activated receptor γ (PPARγ), cytosolic FABP4 and FABP5. The gene discussed is LPL; the disease is obesity due to melanocortin 4 receptor deficiency.